Splenic marginal zone lymphoma: hydra with many heads?
نویسندگان
چکیده
In this issue of the Journal, Baseggio et al. 1 report on a series of 24 patients with CD5-positive, t(11;14)-negative splenic marginal zone lymphoma (SMZL) diagnosed by means of cytology and flow cytometry of peripheral blood. All the patients were splenectomized at diagnosis or during follow-up and, consequently, spleen specimens were available for histological examination in all cases. The biological features of the CD5-positive SMZL cases did not appear to be different from those of a comparative series of 42 CD5-negative SMZL cases with the exception of a tendency to a more mutated immunoglobulin variable heavy chain genes (IGHV) status. Clinically, CD5-positive SMZL were characterized only by more marked lymphocytosis at diagnosis and more frequent diffuse bone marrow infiltration. No significant differences were found in outcome.
منابع مشابه
CD5 expression identifies a subset of splenic marginal zone lymphomas with higher lymphocytosis: a clinico-pathological, cytogenetic and molecular study of 24 cases.
BACKGROUND Classically, splenic marginal zone B-cell lymphoma is characterized by the absence of CD5 expression. Cases of apparent splenic marginal zone B-cell lymphoma showing CD5 expression, as diagnosed by blood studies, have been described; however, in the absence of histological evidence, the correct diagnosis of these cases is controversial because of possible confusion with other CD5-pos...
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1. Spina V, Khiabanian H, Messina M, et al. The genetics of nodal marginal zone lymphoma. Blood. 2016; 128(10):1362-1373. 2. Thieblemont C, Molina T, Davi F. Optimizing therapy for nodal marginal zone lymphoma. Blood. 2016; 127(17):2064-2071. 3. Kanellis G, Roncador G, Arribas A, et al. Identification of MNDA as a new marker for nodal marginal zone lymphoma. Leukemia. 2009;23(10): 1847-1857. 4....
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ورودعنوان ژورنال:
- Haematologica
دوره 95 4 شماره
صفحات -
تاریخ انتشار 2010